My long-time readers will know that I LOVE I-Spy charm squares and am always looking for new ways to use them. (I host I-Spy Square Swaps about once a year and also sell I-Spy charm sets in my Etsy Shop.) You wouldn't necessarily need to use I-Spy squares. Lots of quilt shops sell charm square packs where you can get a few squares from each fabric in a favorite fabric line.
Last year a dear family friend lost her battle with cancer. While visiting her family, they let me choose some fabric from her stash. She was an artist and LOVED color, so I chose this bright rainbow zebra to make a quilt for her grand-baby who was born a few months later.
Some of the I-Spy Squares are just fun bright cheery squares that filled out the colors needed for a rainbow border, but about half of them where specifically chosen because they reminded me of hers and her children's interests...camping, outdoors, flowers, healthy food, pugs, computers, and more.